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The structural basis of GABA-gated chloride channels in mammalian brain is presently explored by the functonal expression of cDNAs coding for the α, β or γ-subunits of the receptor and their isoforms. In this context, we expressed the cloned cDNA coding for the rat β 1 -subunit of the GABA A receptor in the Xenopus oocyte. Surprisingly, efficient expression of a functional ion channel...
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