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Protein‐Protein‐Wechselwirkungen können das Falten einer fehlgeordneten Region umfassen, um so die bindende Grenzfläche zu erhalten. In der Zuschrift auf S. 9942 ff. beschreiben J. Y. Suh et al. den gegenteiligen Fall: von lokalem Entfalten begleitetes Binden. An der Struktur eines an die Extra‐Domäne B von Fibronectin gebundenen maßgeschneiderten Peptids wird ein gekoppeltes Entfalten und Binden...
Aptides, a novel class of high‐affinity peptides, recognize diverse molecular targets with high affinity and specificity. The solution structure of the aptide APT specifically bound to fibronectin extradomain B (EDB), which represents an unusual protein–protein interaction that involves coupled unfolding and binding, is reported. APT binding is accompanied by unfolding of the C‐terminal β strand of...
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