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Background Imidazoline I 3 receptors (I-3R) can regulate insulin secretion in pancreatic β-cells. It has been indicated that allantoin ameliorates hyperglycemia by activating imidazoline I 2 receptors (I-2R). Thus, the effect of allantoin on I-3R is identified in the present study. Methods We used male Wistar rats to screen allantoin’s ability for lowering...
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