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We previously showed that the metabotropic glutamate receptor 1α (mGluR1α) has a sensitivity to extracellular polyvalent cations such as Ca 2+ and Gd 3+ as well as glutamate. Here we show that mGluR1α-mediated responses to these ligands are modulated by the scaffold protein Homer. When HEK293 cells were transiently cotransfected with Homer 1c and mGluR1α, the maximum rate...
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