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Avascularity of normal cornea is a result of homeo-stasis between anti-angiogenic and pro-angiogenic stimuli. Disruption of this delicate balance during corneal wound healing can lead to pathological corneal vascularization. Several unique characteristics in the ocular surface epithelia modulate corneal avascularity. Normal cornea contains heparan sulfate to prevent the release of potent angiogenic...
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