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With the final aim to overcome the tolerance phenomenon which frequently takes place during the therapeutical use of organic nitrates (NTG, nitoglycerin, IS-5MN, isosorbide-5-mononitrate, ISDN, isosorbide dinitrate) for the treatment of angina pectoris, we have synthesized new compounds by inserting different aminoacids between the thioproline and the hexitol or aminodeoxyhexitol moieties of a series...
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