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Site-directed mutagenesis of two sets of three periodic leucine residues which appear at every seventh position in the C-terminal region of human interleukin-6 (IL-6) was performed. Both receptor-binding and immunoglobulin (Ig)-induction activities of a triple mutant Leu 168,175,182 ->Val were only 1% compared with those of wild-type IL-6...
Amino acid substitutions of human interleukin-6 (IL-6) were performed. Single substitution Met 162 -> Ala and double substitutions Leu 159,166 -> Val resulted in a significant decrease of IL-6 activity in the production of immunoglobulin (lg) from B-cells. Single substitution Leu 166 ->Val or Leu 15 ...
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