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The aberrant metabolism of amyloid‐β protein (Aβ) in the human brain has been implicated in the etiology of Alzheimer disease (AD). γ‐Secretase is the enzyme that generates various forms of Aβ, such as Aβ40 and Aβ42, the latter being an aggregation‐prone toxic peptide that is involved in the pathogenesis of AD. Recently, we found that clathrin‐mediated endocytosis of γ‐secretase affects the production...
Accumulating evidence suggests that endocytic pathway deficits are involved in Alzheimer's disease pathogenesis. Several reports show that endocytic disturbance affects β‐amyloid peptide (Aβ) cleavage from β‐amyloid precursor protein (APP). Presenilin‐1 (PS1) is the catalytic core of the γ‐secretase complex required for Aβ generation. Previously, we showed that aging induces endocytic disturbance,...
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