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Background
Human herpesvirus 6 (HHV‐6) reactivation is relatively common after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). However, the incidence of HHV‐6 reactivation and the clinical outcomes following unmanipulated haploidentical HSCT (haplo‐HSCT) remain unknown.
Method
We prospectively monitored blood HHV‐6 DNA using real‐time quantitative polymerase chain reaction weekly...
Delayed platelet engraftment (DPE) is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This phenomenon is also a predictor of increased treatment-related mortality and poor survival. Therefore, therapies that promote platelet engraftment to prevent DPE are needed. This prospective randomized controlled trial was designed to investigate whether recombinant...
BACKGROUND:Many patients who require allogeneic hematopoietic stem cell transplantation (allo‐HSCT) lack a human leukocyte antigen (HLA)‐matched donor. Recently, a new strategy was developed for HLA‐mismatched/haploidentical transplantation from family donors without in vitro T cell depletion (TCD).
METHODS:Over the past 9 years, 756 patients underwent haploidentical transplantation using a protocol...
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