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Cover Caption: The cover image is based on the Research Article Drug upgrade: A complete methodology from old drug to new chemical entities using Nematic Protein Organization Technique by Judith Eschbach et al., https://doi.org/10.1002/ddr.22151.
Drug repurposing is used to propose new therapeutic perspectives. Here, we introduce “Drug Upgrade”, that is, characterizing the mode of action of an old drug to generate new chemical entities and new therapeutics. We proposed a novel methodology covering target identification to pharmacology validation. As an old drug, we chose hydroxychloroquine (HCQ) for its well‐documented clinical efficacy in...
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