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Water-soluble three-dimensional porous supramolecular organic frameworks (SOFs) have been demonstrated as a new generation of homogeneous polycationic platforms for anti-cancer drug delivery. The new SOF drug delivery systems (sof-DDSs) can adsorb dianionic pemetrexed (PMX), a clinically used chemotherapeutic agent instantaneously upon dissolving in water, which is driven by both electrostatic attraction...
Four water-soluble porous supramolecular organic framework drug delivery systems (sof-DDSs) have been used to adsorb doxorubicin (DOX) in water at physiological pH of 7.4, which is driven exclusively by hydrophobicity. The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water. The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance...
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