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A set of 32 natural and synthetic coumarins were tested in order to evaluate their activity on human leukemic cells (K562/R7) overexpressing P-glycoprotein (P-gp). Their ability to reduce the P-gp-mediated drug efflux of daunorubicin out of cells was evaluated at 10μM. Four natural compounds, previously isolated from Calophyllum dispar (Clusiaceae) and substituted by a common α-(hydroxyisopropyl)dihydrofuran...
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