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We report efficient, one-flask procedures for the synthesis of a family of 14 analogs of AZTp 4 A and Ap 4 A containing BH 3 , S, or Se, along with two bisphosphonate analogs of Ap 4 A. These compounds should slow unwanted enzymatic hydrolysis and have the potential to create unique binding interactions in biochemical and structural studies of the excision reaction...
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