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Equilibrium calculations indicate that the Gd3+ chelates used as contrast agents in MRI may partly dissociate in the body fluids. However, the results of the kinetic studies point to the proton, Cu2+ and Zn2+ assisted dissociation of Gd3+ complexes being slow at pH > 5. The excretion of these contrast agents from the body is relatively fast so that the system is far from the equilibrium and the...
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