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REDOR-based experiments with simultaneous 1H–13C and 1H−15N dipolar dephasing are explored for investigating intermolecular protein–protein interfaces in complexes formed by a U–13C,15N-labeled protein and its natural abundance binding partner. The application of a double-REDOR filter (dREDOR) results in a complete dephasing of proton magnetization in the U–13C,15N-enriched molecule while the proton...
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