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To evaluate the effect and its mechanism of aminoguanidine (AG) on small-bowel protection after whole-abdominal irradiation (WAI) in rats.Male Sprague-Dawley rats (300–400 g) subjected to 12 Gy WAI were used for the study. Aminoguanidine at a dose of 50–800 mg/kg was administered by the gavage route 2 h before WAI. Mucosal damage of small bowel was evaluated by the grade of diarrhea and crypt survival;...
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