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One of the mechanisms ensuring immunological unresponsiveness or tolerance depends on the action of CD8 + lymphocytes. In this paper, we report that, in healthy subjects, a subset of CD8 + CD28 - T cells suppresses the specific response to TSH receptor (TSHR) of CD4 + clones. Suppression was highly specific, required cell-cell interaction, and was not mediated by cytotoxicity...
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