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To study the role of radiotherapy and tamoxifen after breast-conserving surgery (BCS) in patients with a favourable prognosis, a clinical trial was initiated by the German Breast Cancer Study Group. Between 1991 and 1998, 361 patients (pT1pN0M0, aged 45–75 years, receptor positive, grade I–II) were randomised to radiotherapy (yes/no) and tamoxifen for 2 years (yes/no) in a 2×2 factorial design; the...
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