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The effect of novel surfactants on the aqueous solubility and the permeability of paclitaxel across a Caco‐2 cell monolayer were examined in this work. The solubility and permeability of paclitaxel was evaluated in the presence of four soft surfactants (SS) KXN441, KXN424, KXN437, and KXN 337 and Solutol® HS15. All surfactants increased the aqueous solubility of paclitaxel. Caco‐2 cell membrane integrity...
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