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In article number 2002861, Thomas P. Davis, Stephen J. Kent, Nghia P. Truong, and co‐workers introduce an artificial microvascular network to characterize cellular interactions of nanomaterials under human blood flow conditions. This innovative platform is easy to set up in any lab and can be applied to future studies of any type of nanoparticles, paving the way for the rational design of nanomedicines...
A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside nanoparticles to prolong blood circulation time and to enhance interactions with targeted cells. During circulation and depending on the selected application (e.g., cancer drug delivery or immune modulators), nanoparticles are required to possess low or high interactions with cells in human blood and blood vessels...
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