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Successful gene therapy for cancer treatment and various human genetic diseases relies on high efficient gene carriers, and many carriers can efficiently deliver plasmid DNA to cells, while most of them are unefficient in siRNA delivery. In this study, a series of amphiphilic copolymers are synthesized for pDNA and siRNA delivery by grafting hydrophobic polyalanine to polyethylenimine (named PPAs)...
A series of amphiphilic multi‐armed PPn copolymers were prepared by ROP of Phe‐NCA with PEI‐25k as a macroinitiator. The particle size of the PPn/DNA complexes was about 100 nm and the zeta potentials were below 20 mV. An MTT assay demonstrated that all the PPn copolymers had lower cytotoxicity compared to PEI‐25k. In vitro gene transfection studies were also conducted in HeLa, 293 and CT 26 cells...
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