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A disintegrin and metalloprotease (ADAM)–33 is a susceptibility gene for asthma and chronic obstructive pulmonary disease whose function remains unknown.Because asthmatic bronchoalveolar lavage fluid contains high levels of soluble ADAM33 (sADAM33), which includes the catalytic domain, we postulated that its release from cell membranes might play functional roles in airway remodeling by promoting...
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