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Background: Pyrimidine nucleoside phosphorylase (PYNP) catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway. In lower organisms (e.g. Bacillus stearothermophilus) PYNP accepts both thymidine and uridine, whereas in mammalian and other higher organisms it is specific for thymidine (designated thymidine phosphorylase, TP). PYNP shares 40% sequence similarity...
Two new crystal forms of Escherichia coli thymidine phosphorylase (EC 2.4.2.4) have been found; a monoclinic form (space group P2 1 ) and an orthorhombic form (space group I222). These structures have been solved and compared to the previously determined tetragonal form (space group P4 3 2 1 2). This comparison provides evidence of domain movement of the α (residues 1 to 65,...
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