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Outline of workshop:Reactive amino groups on antibodiesIsothiocyanates + aminesRadiometals and their chelatesSelection of radionuclideRadionuclides for radioimmunoimagingFor radiotherapy, both alpha- and beta-emitters must be consideredBeta emitters for radiotherapyStability of metal ions in aqueous solutionStability of the radiometal chelate in the bodyBifunctional chelating agentsPolyaminocarboxylic...
Radiolabeled monoclonal antibodies are widely used in the detection and treatment of cancer. However, several problems still prevent full clinical exploitation of these reagents. Low tumor/background ratios in immunoscintigraphy and high background radioactivity in therapy are limiting factors. The strategy of pre-targeting may overcome these limitations. One of the strategies is based on the...
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