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TlpA is a temperature-sensing, coiled-coil protein, encoded on the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium. TlpA was previously presumed to play a role in the pathogenicity of Salmonella. Herein we show that TlpA is tightly regulated, differentially expressed in response to environmental and physiological signals, and can be secreted in vitro. Expression of tlpA was found...
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