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Activation of transducin-GDP by NaF is mainly mediated by aluminofluoride or beryllofluoride complexes acting as GTP γ-phosphate analogs. In millimolar magnesium, NaF at concentrations above 3 mM is active even in the absence of aluminium or beryllium. This activation has a Hill coefficient of 3 with respect to F - , and its rate is linear with respect to Mg 2+ concentrations...
Fluoride activation of the cGMP cascade of vision requires the presence of aluminum, and is shown to be mediated by the binding of one AlF- 4 to the GDP/GTP-binding subunit of transducin. The presence of GDP in the site is required: AlF 4- is ineffective when the site is empty or when GDPszS is substituted for GDP. This sensitivity to the sulfur of GDPszS suggests that AlF ...
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