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Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-secretase complex, and APP CTFβ, a γ-secretase substrate, can be isolated from cultured cells and brain by several different fractionation procedures that are compatible with in vitro γ-secretase assays. Analysis of these gradients for amyloid β protein (Aβ) and CTFγ production indicated that γ-secretase activity...
The basis for therapeutic strategies targeting the amyloid-β protein (Aβ) has come from studies showing that accumulation and aggregation of the Aβ within the brain is likely to cause Alzheimer's disease (AD). Along with an ever-increasing understanding of Aβ metabolism, many potential therapeutic strategies aimed at altering Aβ metabolism have emerged. Among the more intriguing targets for therapy...
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