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Vaccinations with Aβ1-42 have been shown to reduce amyloid burden in transgenic models of Alzheimer’s disease (AD). We have further tested the efficacy of Aβ1-42 immunization in the Tg2576 mouse model of AD by immunizing one group of mice with minimal Aβ deposition, one group of mice with modest Aβ deposition, and one group with significant Aβ deposition. The effects of immunization on Aβ deposition...
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