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Objective:The 5‐lipoxygenase (5LO) enzyme is upregulated in Alzheimer disease (AD), and its genetic absence reduces Aβ levels in APP mice. However, its functional role in modulating tau neuropathology remains to be elucidated.
Methods:To this end, we generated triple transgenic mice (3xTg‐AD) overexpressing neuronal 5LO and investigated their phenotype.
Results:Compared with controls, 3xTg‐AD mice...
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