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Allosteric regulation of enzyme activity plays important metabolic roles. Here we review the allostery of enzymes of amino-acid metabolism conferred by a discrete domain known as the ACT domain. This domain of 60–70 residues has a βαββαβ topology leading to a four-stranded β 4 β 1 β 3 β 2 antiparallel sheet with two antiparallel helices on one face. Extensive sequence...
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