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FocA belongs to the pentameric FNT (formate‐nitrite transporter) superfamily of anion channels, translocating formate bidirectionally across the cytoplasmic membrane of Escherichia coli and other microorganisms. While the membrane‐integral core of FocA shares considerable amino acid sequence conservation with other FNT family members, the soluble cytoplasmic N‐terminal domain does not. To analyze...
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