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Cancer chemotherapy relies to a great extent on the use of drugs like doxorubicin, etoposide, and camptothecin derivatives, which are targeted at topoisomerases. These enzymes that resolve DNA topological constraints in cells are the primary targets for a large diversity of natural products extracted from plants, microorganisms or, as reviewed here, from marine organisms. Marine products capable of...
A library of substituted chromeno[3,4-b]indoles was developed as Lamellarin isosters. Synthesis was achieved from indoles after a four-step pathway sequence involving C-3 iodination, a Suzuki cross-coupling reaction, and a one pot deprotection/lactonisation step. Twenty final compounds were tested in order to determine their activity against topoisomerase I and kinases, the two major biological activities...
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