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HL-60 cancer cells were treated with a series of novel acridine derivatives (derivatives 1–4) in order to test the compounds’ ability to inhibit both cancer cell growth and topoisomerase I and II activity. Binding studies of derivatives 1–4 with calf thymus DNA were also performed using a number of techniques (UV–Vis and fluorescence spectroscopy, thermal denaturation, linear dichroism and viscometry)...
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