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Genetically modified mice represent a tremendous advancement for studying effects of disease-related mutations in depth with the aim to enlighten molecular and physiological mechanisms underlying correlations between genotype and phenotype. Here we discuss some of the limitations that one may encounter with knockout, knockin and transgenic mice in the study of particular gene mutations related to...
1. Abstract Many important physiological processes involve changes in cell volume, e.g., the transport of salt and water in epithelial cells and the contraction of muscle cells. These cells respond to swelling with a so-called regulatory volume decrease which involves the activation of K+ channels. However, the molecular identity of the involved K+ channels has not been clear, and in particular, the...
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