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Escherichia coli MutY is an adenine glycosylase involved in base excision repair that recognizes OG:A (where OG = 7,8-dihydro-8-oxo-2'-deoxyguanosine) and G:A mismatches in DNA. MutY contains a solvent-exposed polypeptide loop between two of the cysteine ligands to the [4Fe-4S] 2+ cluster, referred to as the iron-sulfur cluster loop (FCL) motif. The FCL is located adjacent to the proposed...
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