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This review examines recent work aimed at revealing the molecular structures of the potassium channel vestibules using the α-K toxin (α-KTx) peptide blockers from the venoms of scorpions. The three subfamilies of α-K toxins are discussed in terms of their specificity for voltage-gated potassium (Kv) channels and for the large-conductance calcium-activated (maxi-K) channel. Among the α-KTx subfamilies,...
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