Search results for: Xiangyang Shi

Items from 1 to 20 out of 132 results

article

Structural and Property Characterizations of Dual‐Responsive Core–Shell Tecto Dendrimers for Tumor Penetration and Gene Delivery Applications

Junjie Liu, Xiaoyu Wang, Xiaolei Li, Cheng Ni, more

Macromolecular Rapid Communications > 45 > 17 > n/a - n/a

Core–shell tecto dendrimers (CSTDs) with excellent physicochemical properties and good tumor penetration and gene transfection efficiency have been demonstrated to have the potential to replace high‐generation dendrimers in biomedical applications. However, their characterization and related biological properties of CSTDs for enhanced tumor penetration and gene delivery still lack in‐depth investigation...

article

Recent advances in multifunctional dendrimer‐based complexes for cancer treatment

Dzmitry Shcharbin, Viktoria Zhogla, Viktar Abashkin, Yue Gao, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 16 > 2 > n/a - n/a

The application of nanotechnology in biological and medical fields have resulted in the creation of new devices, supramolecular systems, structures, complexes, and composites. Dendrimers are relatively new nanotechnological polymers with unique features; they are globular in shape, with a topological structure formed by monomeric subunit branches diverging to the sides from the central nucleus. This...

article

Hyperbranched Polymer‐Based Vaccines for Cancer Immunotherapy

Zhiqiang Wang, Yunqi Guo, Mingwu Shen, Yong Wang, more

Macromolecular Bioscience > 23 > 11 > n/a - n/a

Recently, several immunotherapeutic strategies are extensively studied and entered clinical investigation, suggesting their potential to lead a new generation of cancer therapy. Particularly, a cancer vaccine that combines tumor‐associated antigens and immune adjuvants with a nanocarrier holds huge promise for inducing specific antitumor immune responses. Hyperbranched polymers, such as dendrimers...

article

An Intelligent Vascular Disrupting Dendritic Nanodevice Incorporating Copper Sulfide Nanoparticles for Immune Modulation‐Mediated Combination Tumor Therapy

Yiming Zhang, Zhijun Ouyang, Mengsi Zhan, Rui Yang, more

Small > 19 > 39 > n/a - n/a

Development of intelligent nanoplatforms that can simultaneously target multiple factors associated with tumor growth and metastasis remains an extreme challenge. Here, an intelligent dendritic nanodevice incorporating both copper sulfide nanoparticles (CuS NPs) and 5,6‐dimethylxanthenone‐4‐acetic acid (DMXAA, a vascular disrupting agent) within the dendrimer internal cavities and surface modified...

article

Phosphorous Dendron Micelles as a Nanomedicine Platform for Cooperative Tumor Chemoimmunotherapy via Synergistic Modulation of Immune Cells

Mengsi Zhan, Jieru Qiu, Yu Fan, Liang Chen, more

Advanced Materials > 35 > 3 > n/a - n/a

Design of effective nanomedicines to modulate multiple immune cells to overcome the immune‐suppressive tumor microenvironment is desirable to improve the overall poor clinical outcomes of immunotherapy. Herein, a nanomedicine platform is reported based on chemotherapeutic drug doxorubicin (DOX)‐loaded phosphorus dendron micelles (M‐G1‐TBPNa@DOX, TBP, tyramine bearing two dimethylphosphonate) with...

article

Chemotherapy Mediated by Biomimetic Polymeric Nanoparticles Potentiates Enhanced Tumor Immunotherapy via Amplification of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

Yunqi Guo, Yu Fan, Zhiqiang Wang, Gaoming Li, more

Advanced Materials > 34 > 47 > n/a - n/a

Construction of multifunctional nanoplatforms to elevate chemotherapeutic efficacy and induce long‐term antitumor immunity still remains to be an extreme challenge. Herein, the design of an advanced redox‐responsive nanomedicine formulation based on phosphorus dendrimer–copper(II) complexes (1G₃‐Cu)‐ and toyocamycin (Toy)‐loaded polymeric nanoparticles (GCT NPs) coated with cancer cell membranes (CM)...

article

The design and application of IRobotQ3D for simulating robotics experiments in K‐12 education

Zehui Zhan, Baichang Zhong, Xiangyang Shi, Qiuji Si, more

Computer Applications in Engineering Education > 30 > 2 > 532 - 549

This study developed a robotic online simulation platform (i.e., IRobotQ3D) for K‐12 education, which realized several main fundamental functions, such as the three‐dimensional (3D) structure design of the robot, a combination of components, graphical programming, and motion simulation. Based on the PhysX physics engine, this system regarded the robot and interactive environment as a rigid body and...

article

Metal–Phenolic‐Network‐Coated Dendrimer–Drug Conjugates for Tumor MR Imaging and Chemo/Chemodynamic Therapy via Amplification of Endoplasmic Reticulum Stress

Zhiqiang Wang, Yunqi Guo, Yu Fan, Jingwen Chen, more

Advanced Materials > 34 > 7 > n/a - n/a

Amplification of endoplasmic reticulum stress (ERS) to realize enhanced cancer therapy has been considered to be unique in current cancer nanomedicine design. Herein, the design of metal–phenolic‐network‐coated dendrimer–drug conjugates as a novel theranostic nanoplatform based on ERS amplification is reported. In the design, acetylated generation‐5 poly(amidoamine) dendrimers are conjugated with...

article

Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors

Xin Li, Haitao Sun, Helin Li, Chaolei Hu, more

Advanced Functional Materials > 31 > 26 > n/a - n/a

The facile preparation, modular design, and multi‐responsiveness are extremely critical for developing pervasive nanoplatforms to meet heterogeneous applications. Here, cationic nanogels (NGs) are modularly engineered with tunable responsiveness, versatility, and biodegradation. Cationic PVCL‐based NGs with core/shell structure are fabricated by facile one‐step synthesis. The formed PVCL‐NH₂ NGs exhibit...

article

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

Yunqi Guo, Mingwu Shen, Xiangyang Shi

Macromolecular Bioscience > 21 > 4 > n/a - n/a

Design of intelligent hybrid nanoparticles that can integrate diagnosis and therapy components plays an important role in the field of nanomedicine. Poly(amidoamine) (PAMAM) dendrimers possessing a unique architecture and tunable functional groups have been widely developed for various biomedical applications. Carbon dots (CDs) are considered as a promising fluorescence probe or drug delivery system...

article

Targeted Combination of Antioxidative and Anti‐Inflammatory Therapy of Rheumatoid Arthritis using Multifunctional Dendrimer‐Entrapped Gold Nanoparticles as a Platform

Jin Li, Liang Chen, Xiaoying Xu, Yu Fan, more

Small > 16 > 49 > n/a - n/a

Abundant reactive oxygen species and tumor necrosis factor‐α (TNF‐α) cytokine supply of M1‐type macrophages boost rheumatoid arthritis (RA) pathological process. For efficient RA therapy, here a multifunctional nanoplatform is presented based on generation 5 (G5) poly(amidoamine) dendrimer‐entrapped gold nanoparticles (Au DENPs) to achieve co‐delivery of antioxidant alpha‐tocopheryl succinate (α‐TOS)...

article

Potent Anticancer Efficacy of First‐In‐Class Cu^II and Au^III Metaled Phosphorus Dendrons with Distinct Cell Death Pathways

Liang Chen, Yu Fan, Jieru Qiu, Régis Laurent, more

Chemistry – A European Journal > 26 > 26 > 5903 - 5910

First‐in‐class Cu^II and Au^III metaled phosphorus dendrons were synthesized and showed significant antiproliferative activity against several aggressive breast cancer cell lines. The data suggest that the cytotoxicity increases with reducing length of the alkyl chains, whereas the replacement of Cu^II with Au^III considerably increases the antiproliferative activity of metaled phosphorus dendrons. Very...

article

Dendrimer‐Based Nanosensitizers: Targeted Tumor Hypoxia Dual‐Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer‐Based Nanosensitizers (Adv. Funct. Mater. 13/2020)

Yu Fan, Wenzhi Tu, Mingwu Shen, Xuming Chen, more

Advanced Functional Materials > 30 > 13 > n/a - n/a

In article number 1909285, Yong Liu, Xiangyang Shi, and co‐workers report hypoxia‐targeted dendrimer‐based nanodevices, which can be employed as a contrast agent for dual mode CT/MR imaging of hypoxic tumors. Moreover, under X‐ray irradiation, the developed nanohybrids enable enhanced reactive oxygen species production, promote DNA damage, and prevent DNA repair, facilitating sensitized radiotherapy...

article

Targeted Tumor Hypoxia Dual‐Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer‐Based Nanosensitizers

Yu Fan, Wenzhi Tu, Mingwu Shen, Xuming Chen, more

Advanced Functional Materials > 30 > 13 > n/a - n/a

The efficacy of radiation therapy (RT) is often limited by the poor response of hypoxia inside most solid tumors. The development of a theranostic nanoplatform for precision‐imaging‐guided sensitized RT for tumor hypoxia is still challenging. Herein, the creation of hypoxia‐targeted dendrimer‐entrapped gold nanoparticles complexed with gadolinium(III) (Gd‐Au DENPs‐Nit) for dual‐mode CT/MR imaging...

article

Doxorubicin Encapsulated in TPGS‐Modified 2D‐Nanodisks Overcomes Multidrug Resistance

Tingting Jiang, Changchang Zhang, Wenjie Sun, Xueyan Cao, more

Chemistry – A European Journal > 26 > 11 > 2470 - 2477

Multidrug resistance (MDR) is regarded as a main obstacle for effective chemotherapy, and P‐glycoprotein (P‐gp)‐mediated drug efflux has been demonstrated to be the key factor responsible for MDR. In this study, a novel pH‐responsive hybrid drug delivery system was developed by conjugating d‐α‐tocopheryl polyethylene glycol 1000 succinate (TPGS), a kind of P‐gp inhibitor, on the surface of laponite...

article

PAMAM Dendrimer‐Based Nanodevices for Nuclear Medicine Applications

Tingting Xiao, Du Li, Xiangyang Shi, Mingwu Shen

Macromolecular Bioscience > 20 > 2 > n/a - n/a

Nuclear medicine, involving nuclear medicine imaging and radiotherapy (RT), has become a mainstay of theranostics in the field of nanomedicine and several examples have been successfully translated into clinical practice. The combination of radionuclides with dendrimers has long been investigated in nuclear imaging, such as positron emission tomography (PET) and single‐photon emission computed tomography...

article

Polyethylenimine‐Based Nanogels for Biomedical Applications

Yu Zou, Du Li, Mingwu Shen, Xiangyang Shi

Macromolecular Bioscience > 19 > 11 > n/a - n/a

Nanogels (NGs) are 3‐dimensional (3D) networks composed of hydrophilic or amphiphilic polymer chains, allowing for effective and homogeneous encapsulation of drugs, genes, or imaging agents for biomedical applications. Polyethylenimine (PEI), possessing abundant positively charged amine groups, is an ideal platform for the development of NGs. A variety of effective PEI‐based NGs have been designed...

article

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

Wei Huang, Yunchao Xiao, Xiangyang Shi

Advanced Fiber Materials > 2019 > 1 > 1 > 32-45

Electrospun nanofibers hold a great potential in biomedical applications due to their advantages of large specific surface area, good biocompatibility, easy fabrication and surface modification. In particular, organic/inorganic hybrid nanofibers exhibit enhanced mechanical properties and long-term sustained release or controlled release profile of encapsulated drugs, which enables hybrid nanofibers...

article

Electrospun PEGylated PLGA nanofibers for drug encapsulation and release

Leqiang Zhang, Zhe Wang, Yunchao Xiao, Pengchao Liu, more

Materials Science and Engineering: C > 2018 > 91 > C > 255-262

We report the fabrication of electrospun nanofibers of polyethylene glycol (PEG)-modified poly (lactic-co-glycolic acid) (PLGA) with a fast release profile for biomedical applications. In this work, PLGA was first covalently modified with methoxy poly (ethylene glycol) amine (mPEG-NH₂). The formed PEGylated PLGA (PLGA-PEG) was then mixed with a model drug amoxicillin (AMX) for subsequent fabrication...

article

New opportunities of dendrimers for theranostic approaches to personalized medicine

Jean-Pierre Majoral, Xiangyang Shi, Serge Mignani

Science China Materials > 2018 > 61 > 11 > 1365-1366

Publication date

Last year (2)
Last 3 years (8)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Publication type

article (131)
book (1)

Keywords

DENDRIMERS (23)
GOLD NANOPARTICLES (16)
TUMORS (11)
IRON OXIDE NANOPARTICLES (10)
MR IMAGING (9)
CT IMAGING (7)
ELECTROSPINNING (6)
MAGNETIC RESONANCE IMAGING (6)
DENDRIMER (5)
DOXORUBICIN (5)
NANOPARTICLES (5)
POLYETHYLENEIMINE (5)
FOLIC ACID (4)
GENE DELIVERY (4)
TARGETING (4)
ANTIBACTERIAL ACTIVITY (3)
BIOCOMPATIBILITY (3)
CANCER CELLS (3)
DRUG DELIVERY (3)
ELECTROSPUN NANOFIBERS (3)
IMMUNOGENIC CELL DEATH (3)
MOLECULAR IMAGING (3)
PHOTOTHERMAL THERAPY (3)
TARGETED CANCER THERAPY (3)
ALPHA-TOCOPHERYL SUCCINATE (2)
CELL CULTURE (2)
COMPUTED TOMOGRAPHY (2)
CONTRAST AGENTS (2)
DRUG DELIVERY SYSTEMS (2)
DUAL‐MODE CT/MR IMAGING (2)
FUNCTIONALIZATION OF POLYMERS (2)
GADOLINIUM (2)
GD(OH)3 NANOPARTICLES (2)
GOLD–SILVER ALLOY NANOPARTICLES (2)
HALLOYSITE NANOTUBES (2)
HYALURONIC ACID (2)
HYDROTHERMAL SYNTHESIS (2)
HYPERBRANCHED POLYMERS AND MACROCYCLES (2)
HYPOXIA TARGETING (2)
IMAGING (2)
IMAGING AGENTS (2)
LAPONITE (2)
MANGANESE OXIDE NANOPARTICLES (2)
MULTIWALLED CARBON NANOTUBES (2)
NANOFIBERS (2)
NANOGELS (2)
OPTICAL IMAGING (2)
PAMAM DENDRIMERS (2)
PEGYLATION (2)
PHOSPHORUS DENDRIMERS (2)
POLYACRYLIC ACID (2)
POLYETHYLENE GLYCOL (2)
POLYETHYLENIMINE (2)
RADIOSENSITIZATION (2)
RGD PEPTIDE (2)
STABILITY (2)
SUSTAINED RELEASE (2)
SYNTHESIS (2)
T1‐WEIGHTED MR IMAGING (2)
T2‐WEIGHTED MR IMAGING (2)
THERANOSTICS (2)
TOYOCAMYCIN (2)
VIRULENCE REGULATORY PATHWAYS (2)
X-RAY ATTENUATION (2)
XYLELLA FASTIDIOSA (2)
XYLEM FLUID (2)
IN VIVO (1)
V. SMALLIANA (1)
V. VINIFERA (1)
XYLELLA FASTIDIOSA (1)
2-METHOXYESTRADIOL (1)
3-AMINOPROPYLTRIMETHOXYSILANE (1)
3D+PHYSICS (1)
ACETYLATION (1)
ACOUSTOFLUIDIC CHIP (1)
AGGREGATION (1)
ALGINATE (1)
ALPHA‐TOCOPHERYL SUCCINATE (1)
AMOXICILLIN (1)
AMPLIFICATION OF ENDOPLASMIC RETICULUM STRESS (1)
ANTICANCER THERAPY (1)
ANTIGEN DELIVERY (1)
ANTIPROLIFERATION (1)
ANTITUMORAL AND ANTIBACTERIAL PROPERTIES (1)
APOPTOSIS (1)
AQUEOUS-PHASE SYNTHESIS (1)
AU(I) OR AU(III) COMPLEXES (1)
BIOFILM FORMATION (1)
BIOIMAGING (1)
BIOMEDICAL APPLICATIONS (1)
BLOOD POOL (1)
BLOOD POOL CT IMAGING (1)
CANCER (1)
CANCER DIAGNOSIS (1)
CANCER THERANOSTICS (1)
CANCER THERAPY (1)
CANCER VACCINES (1)
CARBON DOTS (1)
CARBON NANOTUBE (1)
CARBON NANOTUBES (1)
more

Data set

Elsevier (57)
Wiley (35)
ACS (25)
Springer (15)

Journal

Biomaterials (14)
Journal of Controlled Release (12)
Colloids and Surfaces B: Biointerfaces (9)
Colloids and Surfaces A: Physicochemical and Engineering Aspects (7)
Journal of Applied Polymer Science (5)
Macromolecular Bioscience (5)
The Journal of Physical Chemistry C (5)
Advanced Functional Materials (4)
Nano Letters (4)
Particle & Particle Systems Characterization (4)
Advanced Materials (3)
Chemistry – A European Journal (3)
Langmuir (3)
Materials Science and Engineering: C (3)
Science China Materials (3)
Bioconjugate Chemistry (2)
European Journal of Plant Pathology (2)
Journal of Hazardous Materials (2)
Molecular Pharmaceutics (2)
Nanoscale Research Letters (2)
Progress in Polymer Science (2)
Small (2)
The Journal of Physical Chemistry B (2)
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2)
ACS Applied Materials & Interfaces (1)
Acta Biomaterialia (1)
Advanced Fiber Materials (1)
Advances in Colloid and Interface Science (1)
Analytical Chemistry (1)
Biomacromolecules (1)
Carbohydrate Polymers (1)
Carbohydrate Research (1)
Chemistry of Materials (1)
Chinese Journal of Chemistry (1)
Computer Applications in Engineering Education (1)
Coordination Chemistry Reviews (1)
Drug Discovery Today (1)
ELECTROPHORESIS (1)
Environmental Science & Technology (1)
FEMS Microbiology Letters (1)
Food Analytical Methods (1)
International Journal of RF and Microwave Computer‐Aided Engineering (1)
Iranian Polymer Journal (1)
Journal of Nanoparticle Research (1)
Journal of Ovarian Research (1)
Journal of the American Chemical Society (1)
Macromolecular Rapid Communications (1)
Macromolecular Research (1)
Macromolecules (1)
Molecular Imaging and Biology (1)
Pharmaceutical Research (1)
Polymer (1)
Superlattices and Microstructures (1)
more

INFONA - science communication portal

Search results for: Xiangyang Shi

Structural and Property Characterizations of Dual‐Responsive Core–Shell Tecto Dendrimers for Tumor Penetration and Gene Delivery Applications

Recent advances in multifunctional dendrimer‐based complexes for cancer treatment

Hyperbranched Polymer‐Based Vaccines for Cancer Immunotherapy

An Intelligent Vascular Disrupting Dendritic Nanodevice Incorporating Copper Sulfide Nanoparticles for Immune Modulation‐Mediated Combination Tumor Therapy

Phosphorous Dendron Micelles as a Nanomedicine Platform for Cooperative Tumor Chemoimmunotherapy via Synergistic Modulation of Immune Cells

Chemotherapy Mediated by Biomimetic Polymeric Nanoparticles Potentiates Enhanced Tumor Immunotherapy via Amplification of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

The design and application of IRobotQ3D for simulating robotics experiments in K‐12 education

Metal–Phenolic‐Network‐Coated Dendrimer–Drug Conjugates for Tumor MR Imaging and Chemo/Chemodynamic Therapy via Amplification of Endoplasmic Reticulum Stress

Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

Targeted Combination of Antioxidative and Anti‐Inflammatory Therapy of Rheumatoid Arthritis using Multifunctional Dendrimer‐Entrapped Gold Nanoparticles as a Platform

Potent Anticancer Efficacy of First‐In‐Class Cu^II and Au^III Metaled Phosphorus Dendrons with Distinct Cell Death Pathways

Dendrimer‐Based Nanosensitizers: Targeted Tumor Hypoxia Dual‐Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer‐Based Nanosensitizers (Adv. Funct. Mater. 13/2020)

Targeted Tumor Hypoxia Dual‐Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer‐Based Nanosensitizers

Doxorubicin Encapsulated in TPGS‐Modified 2D‐Nanodisks Overcomes Multidrug Resistance

PAMAM Dendrimer‐Based Nanodevices for Nuclear Medicine Applications

Polyethylenimine‐Based Nanogels for Biomedical Applications

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

Electrospun PEGylated PLGA nanofibers for drug encapsulation and release

New opportunities of dendrimers for theranostic approaches to personalized medicine

Filter options

Publication date

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Xiangyang Shi

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options