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We report boronate‐caged guanidine‐lipid 1 that activates liposomes for cellular delivery only upon uncaging of this compound by reactive oxygen species (ROS) to produce cationic lipid products. These liposomes are designed to mimic the exceptional cell delivery properties of cell‐penetrating peptides (CPPs), while the inclusion of the boronate cage is designed to enhance selectivity such that cell...
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