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The amelogenin proteins regulate enamel mineral formation in the developing tooth. The human AMELX gene, which encodes the amelogenin proteins, is located within an intron of the Arhgap6gene. ARHGAP6 encodes a RhoGAP, which regulates activity of RhoA, a small G protein involved in intracellular signal transduction. Mice were generated in which the entire ARHGAP6 gene was deleted by Cre-mediated recombination,...
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