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Protons and capsaicin activate overlapping subsets of sensory nerves by opening ion conductances of similar properties. We have used the [ 3 H]resiniferatoxin binding assay utilizing rat spinal cord membranes to elucidate the possible interaction of protons at the vanilloid (capsaicin) receptor. Using low pH (pH 6.0 and pH 5.0) buffers, a time-dependent gradual decrease was observed in specific...
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