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The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA‐based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducible branched polyethylenimine (rBPEI)‐based nanoparticle (NP) system is utilized as...
Front Cover: A reducible branched polyethylenimine (rBPEI)‐based nanoparticle (NP) system is introduced as a siRNA carrier to corneal neovascularization therapy. The rBPEI‐NPs are efficiently degraded into LMW BPEI inside the cytosol to facilitate a release of siRNA targeting NFkB. Eventually, a significant anti‐angiogensis effect without noticeable toxicity is shown. Further details can be found...
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