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Paracrine is an important mechanism in mesenchymal stem cells (MSCs) that promotes tissue regeneration. However, anoikis is attributed to unsuitable adhesion microenvironment hindered this paracrine effect. In this study, a living and injectable porous hydrogel microsphere with long‐term paracrine activity is constructed via the freeze‐drying microfluidic technology and the incorporation of platelet‐derived...
The localization and accumulation of drugs in the body determine their therapeutic effects; however, the specific microstructure of damaged tissues hinders drug delivery. Currently, there is a shortage of effective drug carriers to breach these barriers and achieve efficient tissue and cellular delivery of drugs. In this study, an injectable double positively charged functional hydrogel microsphere...
Inspired by the unique structure and lubrication mechanism of ball bearing, monodisperse, size‐uniform hydrogel spheres are fabricated by Hongyu Zhang, Xiangyang Xu, Wenguo Cui, and co‐workers in article number 2004519 using microfluidic technology, and subsequently modified with pSBMA to form superlubricated hydrogel microspheres using a one‐step bionic grafting approach. The superlubricated hydrogel...
Osteoarthritis, a lubrication dysfunction related disorder in joint, is characterized by articular cartilage degradation and joint capsule inflammation. Enhancing joint lubrication, combined with anti‐inflammatory therapy, is considered as an effective strategy for osteoarthritis treatment. Herein, based on the ball‐bearing‐inspired superlubricity and the mussel‐inspired adhesion, a superlubricated...
Osteoarthritis is a typical degenerative joint disease related to a lubrication deficiency of articular cartilage, which is characterized by increased friction at the joint surface and severe inflammation of the joint capsule. Consequently, therapies combining lubrication restoration and drug intervention are regarded as a promising strategy for the treatment of osteoarthritis. In the present study,...
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