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Lipoic acid, urea, and tryptophan show structural similarities to the vitamin biotin. If these compounds can successfully compete with biotin or a biotinylated protein for binding to avidin, their presence in serum and urine would cause artifacts in avidin-binding assays for biotin. We assessed the ability of lipoic acid and certain analogs, urea, and l-tryptophan and tryptophan derivatives to interfere...
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