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Desorptions‐Elektrosprayionisation löst intakte Proteinkomplexe von Oberflächen ab und ermöglicht deren schnelle Charakterisierung in einem Massenspektrometer. Das Bild zeigt schematisch die Elektrosprühwolke, die gefangene lösliche oder Membranproteine befreit und in die Gasphase transferiert. J. T. S. Hopper, C. V. Robinson et al. demonstrieren in ihrer Zuschrift auf S. 14655 neue Anwendungen, einschließlich...
Mass spectrometry (MS) applications for intact protein complexes typically require electrospray (ES) ionization and have not been achieved via direct desorption from surfaces. Desorption ES ionization (DESI) MS has however transformed the study of tissue surfaces through release and characterisation of small molecules. Motivated by the desire to screen for ligand binding to intact protein complexes...
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