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Skp2 is the substrate recognition subunit of the multi-subunit ubiquitin ligase SCF Skp2 . It consists of an N-terminal F-box domain that binds to the Skp1 subunit and thereby tethers it to the SCF catalytic core, and an elongated C-terminal domain comprising ten Leucine-rich repeats (LRR) that binds the substrate. A small accessory protein, Cks1, is required for SCF Skp2 to target...
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