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AimsLichen sclerosus (LS) is a chronic inflammatory disease of the genital skin of unknown aetiology. The role of LS in penile squamous cell carcinogenesis is not well characterized. HPV has been implicated in both, as have epigenetic changes. The presence of HPV and hypermethylation of the MGMT, p16,RASSF1,RASSF2,TSLC1 and TSP1 genes were studied in penile LS;MGMT,RASSF2 and TSLC1 hypermethylation...
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