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Literature values vary widely for within‐subject test–retest reproducibility of gamma‐aminobutyric acid (GABA) measured with edited magnetic resonance spectroscopy (MRS). Reasons for this variation remain unclear. Here, we tested whether three acquisition parameters—(1) sequence complexity (two‐experiment MEscher–GArwood Point RESolved Spectroscopy [MEGA‐PRESS] vs. four‐experiment Hadamard Encoding...
Disrupted brain gamma‐aminobutyric acid (GABA)/glutamate homeostasis is a promising target for pharmacological intervention in co‐occurring bipolar disorder (BD) and cannabis use disorder (CUD). Gabapentin is a safe and well‐tolerated medication, FDA‐approved to treat other neurological diseases, that restores GABA/glutamate homeostasis, with treatment studies supporting efficacy in treating CUD,...