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Aβ peptide is the major component of senile plaques (SP) which accumulates in AD (Alzheimer's disease) brain. Reports from different laboratories indicate that anesthetics interact with Aβ peptide and induce Aβ oligomerization. The molecular mechanism of Aβ peptide interactions with these anesthetics was not determined. We report molecular details for the interactions of uniformly 15 N labeled...
CopA, a thermophilic ATPase from Archaeoglobus fulgidus, drives the outward movement of Cu + across the cell membrane. Millimolar concentration of Cys dramatically increases (≅800%) the activity of CopA and other P IB -type ATPases (Escherichia coli ZntA and Arabidopsis thaliana HMA2). The high affinity of CopA for metal (≅1 μM) together with the low Cu + –Cys K D (<10...
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