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Mesalazine or 5-aminosalicylic acid (5ASA) is well known for the local treatment of inflammatory gastrointestinal (GI) diseases. These inflammations may occur throughout the GI tract, the most frequently affected areas being the distal ileum and the colon. 5ASA is therefore administered in oral modified release tablets, suppositories, enemas and rectal foams.5ASA is a drug, however, which is rather...
Isosorbide-5-mononitrate (IS5MN) is a widely used cardiovascular drug. Dosage forms have been developed which allow the release of IS5MN over a sustained period of time, resulting in better patient compliance and reduction of nitrate tolerance. Disadvantages of these formulations are the rather time consuming method of manufacture and their IS5MN-releasing profiles. Thus, there is need for a dosage...
We have reported on the pharmaceutical development of a newly invented mesalazine (5ASA) enema formulation. Here we describe the bioperformance of this enema (Asacol(R)). Healthy (non)-smoking subjects (12) participated in a bioavailability study comparing Asacol(R) and Salofalk(R) enemas, each containing 2g of 5ASA. Each subject received the formulations according to a randomized cross-over design...
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