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In this study we have elucidated the effects of allergen-specific antibodies on human DCs and T-cells. Monocyte-derived DCs from allergic patients were exposed to Phl p 5 alone or in complex with Phl p 5-specific human IgG1, IgG4 or IgE and further co-cultured with autologous memory CD4 + T-cells. We demonstrate that DCs treated with Phl p 5/IgE-complexes secrete higher levels of IL-1α, IL-6,...
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